Bulk property differences of a consistent solid form can have a substantial impact on physicochemical properties, leading to significant differences in drug performance between batches. Variability of properties such as dissolution, flowability, bulk density and strength of agglomeration can create downstream problems in formulation processes.
AMRI leverages our team’s extensive experience with process chemistry R&D and manufacturing, combined with solid state expertise and advanced technology, to identify the root cause of bulk property changes and recommend or implement corrective actions.